Alphazyme
Applied DNA and Alphazyme LLC, a Maravai LifeSciences company and global provider of specialty enzymes used in the life sciences sector, announced the successful conclusion of the companies’ previously announced Linea™ RNAP manufacturing scale-up agreement.
The joint process development project resulted in an over 70% reduction in Linea RNAP manufacturing costs and the manufacture of a quantity of Linea RNAP sufficient to support Applied DNA’s anticipated near-term demand for critical starting material for mRNA production.
Dr. James A. Hayward, president and CEO of Applied DNA:
“We are seeing encouraging momentum in the marketplace that we believe validates our biotherapeutics strategy and positions the Company for a return to growth through our LineaRx segment. Third-party evaluations of our Linea IVT platform have consistently reported on its capacity for dsRNA mitigation and reduced workflow complexity. In partnership with Alphazyme, we have now proved that our Linea RNAP, one of two core technologies comprising our Linea IVT platform, can be produced at scale and at a significantly lower unit cost to drive a material improvement in platform profitability. Armed with these improved economics, the near-term initiation of GMP manufacturing capabilities, and new IP protection, we believe we are well positioned to convert new and existing customers to GMP-grade supply agreements for mRNA critical starting materials beginning in the last quarter of calendar 2024.”
Chad Decker, Vice President and General Manager of Alphazyme:
“It has been a privilege to work with Applied DNA and help further the development of the mRNA therapeutic landscape. We built Alphazyme to enable our partners to bring innovative technology to the market with high-quality enzymes manufactured to meet the scalability and cost challenges they face. Our relationship with Applied DNA and the outcome that was delivered from this project are exemplary of this founding vision and the impact we can enable.”